abstract：:The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aor...

journal_title：Canadian journal of physiology and pharmacology

authors： Turgut NH,Temiz TK,Turgut B,Karadas B,Parlak M,Bagcivan I

更新日期：2013-10-01 00:00:00

abstract：:The antioxidant glutathione-S-transferase (GST) is a crucial determinant of the development of ischaemic-reperfusion (I/R) injury, and plays a pivotal role in the regulation of the mitogen activated protein kinase (MAPK) pathways involved in stress response and apoptosis. The aim of this study was to investigate wheth...

journal_title：Canadian journal of physiology and pharmacology

authors： Balatonyi B,Gasz B,Kovács V,Lantos J,Jancsó G,Marczin N,Rőth E

更新日期：2013-08-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K⁺ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization i...

journal_title：Canadian journal of physiology and pharmacology

authors： Szuts V,Ménesi D,Varga-Orvos Z,Zvara Á,Houshmand N,Bitay M,Bogáts G,Virág L,Baczkó I,Szalontai B,Geramipoor A,Cotella D,Wettwer E,Ravens U,Deák F,Puskás LG,Papp JG,Kiss I,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:Activators of the slow delayed rectifier K⁺ current (IKs) have been suggested as promising tools for suppressing ventricular arrhythmias due to prolongation of repolarization. Recently, L-364,373 (R-L3) was nominated to activate IKs in myocytes from several species; however, in some studies, it failed to activate IKs....

journal_title：Canadian journal of physiology and pharmacology

authors： Corici C,Kohajda Z,Kristóf A,Horváth A,Virág L,Szél T,Nagy N,Szakonyi Z,Fülöp F,Muntean DM,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and ca...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun L,Tian X,Gou L,Ling X,Wang L,Feng Y,Yin X,Liu Y

更新日期：2013-07-01 00:00:00

abstract：:In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade infla...

journal_title：Canadian journal of physiology and pharmacology

authors： Magrone T,Perez de Heredia F,Jirillo E,Morabito G,Marcos A,Serafini M

更新日期：2013-06-01 00:00:00

abstract：:Grains are global dietary staples that when consumed in whole grain form, offer considerable health benefits compared with milled grain foods, including reduced body weight gain and reduced cardiovascular and diabetes risks. Dietary patterns, functional foods, and other lifestyle factors play a fundamental role in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Nelson K,Stojanovska L,Vasiljevic T,Mathai M

更新日期：2013-06-01 00:00:00

abstract：:Myopenia or muscle wasting due to ageing, chronic disease, and various medical interventions has been associated with increased mortality, morbidity, and poorer physical function. Attempts through nutrient and exercise interventions have been made to prevent this deterioration. In addition, while a measure of lean bod...

journal_title：Canadian journal of physiology and pharmacology

authors： McDonald C,Bauer J,Capra S

更新日期：2013-06-01 00:00:00

abstract：:Mepivacaine is an aminoamide local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. This study investigated the arachidonic acid metabolic pathways involved in mepivacaine-induced contraction, and elucidated the associated cellular mechanism with a partic...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee HM,Ok SH,Sung HJ,Eun SY,Kim HJ,Lee SH,Kang S,Shin IW,Lee HK,Chung YK,Choi MJ,Bae SI,Sohn JT

更新日期：2013-04-01 00:00:00

abstract：:Connexin43 has been recognized as forming gap junctions in Leydig cells. However, previous work has shown that mouse Leydig cells lacking this connexin do not suffer any limitation of their ability to produce testosterone when stimulated with luteinizing hormone. The objective of this study was to identify additional ...

journal_title：Canadian journal of physiology and pharmacology

authors： Li D,Sekhon P,Barr KJ,Márquez-Rosado L,Lampe PD,Kidder GM

更新日期：2013-02-01 00:00:00

abstract：:Most cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by Ca(2+)/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effect on myocardial fibrosis remains unclear. The present study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chen QQ,Zhang W,Chen XF,Bao YJ,Wang J,Zhu WZ

更新日期：2012-12-01 00:00:00

abstract：:Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated da...

journal_title：Canadian journal of physiology and pharmacology

authors： Calvé A,Noiles W,Sebag IA,Chalifour LE

更新日期：2012-11-01 00:00:00

abstract：:We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated...

journal_title：Canadian journal of physiology and pharmacology

authors： Cameron I,Alam MA,Wang J,Brown L

更新日期：2012-11-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) has physiological roles in the absence of exposure to exogenous ligands, and mediates adaptive and toxic responses to the environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). A readily metabolized AHR agonist, 3-methylcholanthrene, disrupts the expression of mouse he...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee C,Riddick DS

更新日期：2012-10-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Annunzio V,Donato M,Buchholz B,Pérez V,Miksztowicz V,Berg G,Gelpi RJ

更新日期：2012-09-01 00:00:00

abstract：:The aim of this study was to explore the possibility of identifying clusters of children's games based on estimated energy expenditures and (or) intensity when performed in a guided active play format. The study also investigated whether the identified active play game clusters were repeatable when the games were perf...

journal_title：Canadian journal of physiology and pharmacology

authors： Belcastro AN,Morrison KS,Hicks E,Matta H

更新日期：2012-09-01 00:00:00

abstract：:Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonse...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhou K,Kumar U,Yuen VG,McNeill JH

更新日期：2012-08-01 00:00:00

abstract：:We have previously shown that A10 vascular smooth muscle cells (VSMC) exposed to angiotensin II (Ang II) exhibited overexpression of Giα proteins. In the present study, we examined the involvement of different signaling pathways in regulating Ang II induced enhanced expression of Giα proteins in VSMC by using pharmaco...

journal_title：Canadian journal of physiology and pharmacology

authors： Li Y,Anand-Srivastava MB

更新日期：2012-08-01 00:00:00

abstract：:The endothelium, although only a single layer of cells lining the vascular and lymphatic systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 report by Robert Furchgott and John Zawadzki, there has been a phenomenal increase in our knowledge concerning the signalling molecules and path...

journal_title：Canadian journal of physiology and pharmacology

authors： Triggle CR,Samuel SM,Ravishankar S,Marei I,Arunachalam G,Ding H

更新日期：2012-06-01 00:00:00

abstract：:Since the discovery that apolipoprotein E, a cholesterol transport protein, is a major risk factor for Alzheimer's disease (AD) development, there has been a remarkable interest in understanding the many facets of the relationship between cholesterol and AD. Several lines of evidence have demonstrated the importance o...

journal_title：Canadian journal of physiology and pharmacology

authors： Posse de Chaves E

更新日期：2012-06-01 00:00:00

abstract：:This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understand...

journal_title：Canadian journal of physiology and pharmacology

authors： Kozuska JL,Paulsen IM

更新日期：2012-06-01 00:00:00

abstract：:Garlic is a commonly used spice in folk medicine that can exert adverse health effects when given at a high dose. Grape seed and skin extract (GSSE) exhibits a variety of beneficial effects even at a high dose. In the present study we evaluated the toxicity of high-dose garlic treatment on liver and the protective eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamlaoui-Gasmi S,Mokni M,Limam N,N'guessan P,Carrier A,Limam F,Amri M,Aouani E,Marzouki L

更新日期：2012-05-01 00:00:00

abstract：:Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 μg/L) for 8 weeks. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein Ael-A,Abbas AM,El Wakil GA,Elsamanoudy AZ,El Aziz AA

更新日期：2012-05-01 00:00:00

abstract：:Thyrotoxicosis, a condition in which there is an excessive amount of circulating thyroid hormones, leads to reduced glycogen content in different tissues. In this study we analyzed the effects of aerobic swimming training on liver, heart, and skeletal muscle glycogen content in experimentally induced thyrotoxicosis. W...

journal_title：Canadian journal of physiology and pharmacology

authors： Ribeiro LF,Teixeira IP,Aparecido da Silva G,Dalia RA,Júnior MC,Bertolini NO,Rostom de Mello MA,Luciano E

更新日期：2012-05-01 00:00:00

abstract：:The present study investigates the antidiabetogenic effects of Murraya koenigii (L.) Spr. and Ocimum tenuflorum L. on streptozotocin-induced diabetic Swiss mice. Treatment with extracts of M. koenigii (chloroform; MKC) and O. tenuflorum (aqueous; OTA) resulted in proper glucose utilization with an increase in liver gl...

journal_title：Canadian journal of physiology and pharmacology

authors： Dusane MB,Joshi BN

更新日期：2012-03-01 00:00:00

abstract：:The effects of atorvastatin and carboxymethylated β-glucan (CMG) on the lipoprotein-cholesterol (LP-C) and lipoprotein-triglyceride (LP-TG) fractions and subfractions at the early stage of murine hyperlipidemia, and its pleiotropic anti-inflammatory effects, were studied. Atorvastatin and CMG were administered in ICR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Korolenko TA,Tuzikov FV,Cherkanova MS,Johnston TP,Tuzikova NA,Loginova VM,Filjushina EE,Kaledin VI

更新日期：2012-02-01 00:00:00

abstract：:The causes of reduced levels of omega-3 and omega-6 highly unsaturated fatty acids ("HUFA deficiency") in heart failure remain unresolved. HUFA profiles were examined in the serum of 331 patients with failing versus nonfailing heart disease. Arachidonic acid was positively correlated (P < 0.001) with eicosapentaenoic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Rupp H,Rupp TP,Alter P,Maisch B

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to investigate the possible effects of captopril as a promoter in modulating the oxidant-antioxidant balance in rats with type 1 diabetes, and the influence of protein kinase C (PKC) pathways in the production of reactive oxygen species (ROS) induced by bradykinin in type 1 diabetic rats. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodrigues de Araujo G,Granato de Faria K,Lima WG,Pádua Bda C,Rossoni JV Jr,Souza AA,Chianca-Júnior D,Silva ME,Pedrosa ML,Chaves MM,Costa DC

更新日期：2011-12-01 00:00:00

abstract：:Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic a...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdallah DM,Ismael NR

更新日期：2011-11-01 00:00:00

abstract：:The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) i...

journal_title：Canadian journal of physiology and pharmacology

authors： Bruneau BG

更新日期：2011-08-01 00:00:00

abstract：:The guanylin family of peptides has 3 subclasses of peptides containing either 3 intramolecular disulfide bonds found in bacterial heat-stable enterotoxins (ST), or 2 disulfides observed in guanylin and uroguanylin, or a single disulfide exemplified by lymphoguanylin. These peptides bind to and activate cell-surface r...

journal_title：Canadian journal of physiology and pharmacology

authors： Fonteles MC,do Nascimento NR

更新日期：2011-08-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely us...

journal_title：Canadian journal of physiology and pharmacology

authors： Saito Y,Kishimoto I,Nakao K

更新日期：2011-08-01 00:00:00

abstract：:In the literature there appears to be variability in reported levels of certain hormones during haemorrhage, specifically adrenocorticotrophic hormone (ACTH) and β-endorphin. It is possible that this variability may be due to the choice of anaesthetic. Therefore, the effect of 3 common research-only anaesthetic agents...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,Hall WJ,Markos F

更新日期：2011-07-01 00:00:00

abstract：:The effect of sex hormones on vascular reactivity is considered one of the underlying factors contributing to gender differences in cardiovascular functions and diseases. Experiments were designed to investigate the role of androgens in salt-induced hypertension by assessing the relaxation response of isolated aortic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oloyo AK,Sofola OA,Anigbogu CN

更新日期：2011-04-01 00:00:00

abstract：:Changes in dietary omega-6/3 polyunsaturated fatty acids (PUFA) ratios affect anti- and proinflammatory equilibrium. As reperfused myocardial infarction (MI) is an inflammatory pathology that alters the cell integrity of the myocardium but also of other tissues, such as the hippocampus and amygdala, attenuation of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Rondeau I,Picard S,Bah TM,Roy L,Godbout R,Rousseau G

更新日期：2011-03-01 00:00:00

abstract：:Nitric oxide (NO) production occurs through oxidation of the amino acid L-arginine by NO synthase (NOS). NO inhibits platelet activation by increasing the levels of cyclic guanosine monophosphate (cGMP), thus maintaining vascular homeostasis. Our group previously demonstrated (da Silva et al. 2005) an enhancement of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Siqueira MA,Brunini TM,Pereira NR,Martins MA,Moss MB,Santos SF,Lugon JR,Mendes-Ribeiro AC

更新日期：2011-02-01 00:00:00

abstract：:Molecular mechanisms by which exercise exerts cardiovascular benefits are poorly understood. Exercise-induced increase of endothelial NO synthase (eNOS) phosphorylation through the protein kinase Akt has been shown to be a key mechanism underlying the beneficial effect of exercise in coronary artery disease patients. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Pellegrin M,Miguet-Alfonsi C,Berthelot A,Mazzolai L,Laurant P

更新日期：2011-01-01 00:00:00

abstract：:This study investigated the potential of shikonin as an anticancer agent against liver cancer and an in vitro human hepatoma cancer model system. The HepG2 cell line was the hepatoma cancer model in the present study. The inhibitory effect of shikonin on the growth of HepG2 cells was measured by MTT assay. To explore ...

journal_title：Canadian journal of physiology and pharmacology

authors： Yingkun N,Lvsong Z,Huimin Y

更新日期：2010-12-01 00:00:00

abstract：:The novel biological effect of statins in alleviating myocardium fibrosis following infarction has been increasingly recognized, yet the underlying mechanisms are not fully understood. The purpose of this study was to characterize the effect of simvastatin on myocardial fibrosis and collagen I deposition in the non-in...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang J,Xu Y,Pan L,Chen T,Chen Z,Zhao R

更新日期：2010-11-01 00:00:00

abstract：:The goal of the present study was to assess the effects of a restricted feeding schedule (RFS) on postischemic contractile recovery in relation to triacylglycerol (TAG), glycogen, and ATP content. Glucose-6-phosphate dehydrogenase (G6PDH) activity, reduced/oxidized glutathione ratio (GSH/GSSG), and thiobarbituric acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Jaitovich MM,Varela A,Sbarbati C,Hermann R,Torresín ME,Savino EA,Marina Prendes MG

更新日期：2010-10-01 00:00:00